Although marijuana is classified as an illegal drug in many parts of the world, it contains a chemical compound called CBD (cannabidiol) that has great medicinal value. For instance, you can use cannabidiol oil to treat anxiety, pain and even relieve stress. Here is some information on this topic:
What is CBD Oil?
The main ingredient in CBD oil is cannabidiol, which is one of the more than 60 compounds found in cannabis. According to a study published in the Philosophical Transactions of the Royal Society B journal, CBD accounts for about 40% of the chemical compounds found in cannabis. The other major compound is tetrahydrocannabinol (THC), which gives marijuana users a “high.” Fortunately, CBD is non-psychoactive because it does not act on the same brain parts and pathways that THC does. This aspect has made cannabidiol attractive to medical researchers.
Does CBD Get You High?
According to a report published by the National Institute on Drug Abuse Senate Caucus on International Narcotics Control, CBD and THC affect different brain signaling pathways. More specifically, THC interacts with CB1 receptor cells found in the brain and CB2 receptor cells found in the immune system. The euphoria that people experience after taking cannabis is due to the activation of the CB1 receptors. On the other hand, cannabidiol has a low affinity for these receptors, meaning that it does not elicit euphoric experiences.
The Benefits of CBD Oil
Although researchers do not know how CBD really works, several studies have deduced its effects on the human body. To start with, a study published in the Journal of Pharmacology found that it counteracts the intoxicating effects of THC meaning that it does not cause paranoia and anxiety. Another study carried out by Stony Brook University researchers and published in the Journal of Biological Chemistry found that cannabidiol relies on fatty acid binding proteins (FABPs) for intracellular transport. In particular, the Stony Brook University researchers found that CBD uses three FABPs to move from the cell membrane to the interior. As it moves to the cell interior, it inhibits certain intra-cellular chemical reactions by manipulating the FABPs that serve as cannabidiol transporters.
Yet another study published in the British Journal of Pharmacology found that cannabidiol activates the TRPV-1 receptor that plays a role in regulating pain perception, inflammation and body temperature. In addition, it inhibits an enzyme called FAAH, which activates CB1 receptors. The same study also found that CBD inhibits a serotonin receptor known to have anti-depressant effects called 5-HT1A. Moreover, it inhibits brain-signaling activities that involve the CPR55 enzyme leading to lowering of the proliferation rate of cancer cells. These scientific studies have shown that CBD has huge health benefits.
Natural Pain Killer
A report from the National Institutes of Health (NIH) states that clinical trials have demonstrated the ability of cannabidiol to reduce rheumatoid arthritis, cancer, and peripheral neuropathic pain. In spite of this, regulatory bodies such as the Food and Drug Administration have not approved the use of CBD to treat such ailments in the US. Nevertheless, Canada has approved the use of a cannabis extract that has a THC to CBD ratio of 1:1 to treat cancer pain and central neuropathic pain in people with multiple sclerosis especially in cases where opioid therapy does not offer relief.
Another study published by the National Cancer Institute sheds more light on the way cannabidiol ameliorates pain. Researchers involved in this study found that cannabidiol provides pain relief via peripheral, spinal, and supra-spinal modes of action. This means it interacts with ascending and descending pain pathways. At the same time, CBD enhances the release of analgesic opioids to counteract the effect of inflammatory agents like serotonin, keratinocytes, and histamine.
A study published in the Clinical Journal of Pain found that cannabidiol was more effective in managing cancer pain compared to conventional therapies. The results from this study show that CBD gave advanced cancer patients pain relief when strong opioids failed.
CBD Oil for Anxiety
According to the results of a study published in the journal Neuropsychopharmacology, cannabidiol can inhibit anxiety symptoms. These results are a ray of hope for people diagnosed with anxiety disorders such as Generalized Social Anxiety Disorder (SAD) who face difficulties interacting with others socially. Sadly, conventional anti-anxiety drugs rarely lead to full recovery or remission. In fact, the aforementioned study published in the journal Neuropsychopharmacology states that only 30% of people diagnosed with SAD recover after using currently available drugs.
Surprisingly, the study participants reported lower levels of anxiety, discomfort, and cognitive impairment after taking cannabidiol. Furthermore, SAD patients said they were more confident when speaking before others. Scientists involved in this study reckon that CBD inhibits the fear of speaking in public and habituation of anticipatory anxiety.
Functional magnetic resonance imaging (fMRI) showed that CBD inhibited signaling between the anterior cingulate and the amygdala even when SAD patients were exposed to stimuli that would have elicited fear prior to taking cannabidiol. After reviewing these results, researchers concluded that CBD affects paralimbic and limbic brain parts.
CBD Oil And Stress Relief
A National Health Institute (NHI) article states that CBD has anti-stress properties. More specifically, it lowers the heart rate, enabling stressed individuals to relax. A different study published in the International Journal of Neuropsychopharmacology found that CBD has therapeutically beneficial effects on the mental health of humans. To be precise, it prevents development of chronic unpredictable stress (CUS). This is in addition to inhibiting disorders or medical conditions closely associated with stress including depression, anxiety, and psychosis.
Unexpectedly, the researchers involved in this study reckon that the ability of CBD to provide stress relief may be due to neurogenesis. Simply put, neurogenesis is the process of developing new brain neurons. With this in mind, CBD intake led to an increase in hippocampal progenitor proliferation and neurogenesis. In addition, it promoted cell cycle progression and mimicked the proliferative effect witnessed when cannabinoids activate CB1 and CB2 receptor cells.It is also worth noting that the non-psychoactive nature of cannabidiol makes it a suitable anti-stress compound. Scientists recorded these results after administering 30mg of CBD per kilogram of bodyweight to study subjects two hours after subjecting them to a stressful event/experience.
CBD Oil Side Effects
Since CBD has no psychotic effects, it is relatively safe to use. However, you should not exceed the recommended daily dosage, which varies depending on factors such as overall health, medical condition to treat, and bodyweight. Unlike other drugs, CBD oil users tend to require smaller amounts over time. This is because CBD oil consists of fats that take longer to breakdown meaning they remain in the bloodstream for longer. As a result, users require lower dosage over time to experience the same effect, which translates to lower medication costs.
Is CBD Oil Legal?
In the US, CBD oil is regulated in the same manner as medical marijuana. As such, it is legal in some states and illegal in others. Currently, 16 states have legalized medical marijuana. These include Alabama, Florida, Georgia, Iowa, Idaho, Kentucky, Mississippi, Missouri, North Carolina, New York, Oklahoma, South Carolina, Tennessee, Texas, Utah, Virginia, Wisconsin, and Wyoming. Legislators in most of the remaining states are deliberating the pros and cons of enacting laws related to sale of medical marijuana.
CBD Oil for Sale Online
Luckily, consumers in need of CBD oil for therapeutic purposes can place their orders online. A good example is Zen Pro that is available online at a discounted price. Unlike cannabidiol products that the FDA has warned consumers to avoid, Zen Pro contains all-natural ingredients, has no harmful side effects, and is legal in all states without a prescription.
Cannabidiol is cannabis extract that has numerous health benefits including stress relief, pain relief, anxiety relief, inhibiting psychosis, combating inflammation, and inhibiting the spread of cancerous cells. CBD oil products that contain 100% natural ingredients are generally safe. Finally, although only about 16 states have enacted laws legalizing medicinal marijuana, Zen Pro is available throughout the US.